Inhibiting T-cell proliferation
AssigneeBioCryst Pharmaceuticals, Inc.
InventorsShanta Bantia, John A. Montgomery, Philip E. Morris JR.
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Abstract
T-cell inhibition proliferation in a mammalian host by administering effective amounts of 2′-deoxyguanosine and/or prodrugs thereof; and certain PNP inhibitors.
Claims21
A process for enhancing the inhibition of T-cell proliferation in a mammalian host in need thereof by administering to said host an effective amount of at least one member selected from the group consisting of 2′-deoxyguanosine, prodrug of 2′-deoxyguanosine and mixtures thereof, and at least one PNP inhibitor having a Ki of 500 picomolar or less.
A process for enhancing the inhibition of T-cell proliferation in a mammalian host in need thereof by orally administering to said host an effective amount of 2′-deoxyguanosine and administering to said host an effective amount of (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol and said at least one member.
Dependencies are inferred from the claim text.