Antibacterial agents

A compound of Formula II;

• 254
• or a pharmaceutically acceptable salt thereof wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• heteroaryl and substituted heteroaryl,
• halo,
• NO2,
• NO,
• CN,
• ORa,
• 255
• wherein Ra is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,
• 256
• wherein Rb is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• 257
• wherein Rc and Rd are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• NReRf, wherein
• Re and Rf are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 258
• wherein Rb is defined as above;
• wherein Rc and Rd are defined as above;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Re and Rf are taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R3, R4, and R6 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are defined as above;
• or
• R1 and R6 taken together with the atoms to which they are attached to form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• ORa, wherein Ra is defined as above,
• 259
• wherein Rb is defined as above
• wherein Rc and Rd are defined as above;
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are as defined above,
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl, or
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted.

A compound of Formula III:

• 260
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• heteroaryl and substituted heteroaryl,
• halo,
• NO2,
• NO,
• CN,
• ORa,
• 261
• wherein Ra is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,
• 262
• wherein Rb is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• 263
• wherein Rc and Rd are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• NReRf, wherein
• Re and Rf are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 264
• wherein Rb is defined as above;
• wherein Rc and Rd are defined as above;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Re and Rf are taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R4 is H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are defined as above;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• ORa, wherein Ra is defined as above,
• 265
• wherein Rb is defined as above
• wherein Rc and Rd are defined as above;
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are defined as above,
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl, or
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or Spiro heterocyclic can be substituted.

A compound of Formula IV:

• 267
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• heteroaryl and substituted heteroaryl,
• halo,
• NO2,
• NO,
• CN,
• ORa,
• 268
• wherein Ra is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,
• 269
• wherein Rb is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• 270
• wherein Rc and Rd are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C2-C7 alkenyl and substituted alkenyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• NReRf, wherein
• Re and Rf are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 271
• wherein Rb is defined as above;
• wherein Rc and Rd are defined as above;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Re and Rf are taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• ORa, wherein Ra is defined as above,
• 272
• wherein Rc and Rd are defined as above;
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are defined as above,
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl,
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted;
• R6 is H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are defined as above;
• or
• R1 and R6 taken together with the atoms to which they are attached form a 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, optionally substituted by one or more substituents.

A compound of Formula V:

• 274
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• heteroaryl and substituted heteroaryl,
• halo,
• NO2,
• NO,
• CN,
• ORa,
• 275
• wherein Ra is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,
• 276
• wherein Rb is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• 277
• wherein Rc and Rd are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• NReRf, wherein
• Re and Rf are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 278
• wherein Rb is defined as above;
• wherein Rc and Rd are defined as above;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Re and Rf are taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• ORa, wherein Ra is defined as above,
• 279
• wherein Rc and Rd are defined as above;
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are defined as above,
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl, or
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted.

A compound of Formula VI

• 281
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• heteroaryl and substituted heteroaryl,
• halo,
• NO2,
• NO,
• CN,
• ORa,
• 282
• wherein Ra is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,
• 283
• wherein Rb is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• 284
• wherein Rc and Rd are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• NReRf, wherein
• Re and Rf are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 285
• wherein Rb is defined as above;
• wherein Re and Rd are defined as above;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Re and Rf are taken together with the nitrogen to which they are attached form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R3, R4, and R6 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN, or
• NReRf, wherein Re and Rf are defined as above;
• and
• Rg and Rh are defined as for Reand Rf above.

A compound of Formula VII

• 286
• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• or heteroaryl and substituted heteroaryl;
• R2 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• heteroaryl and substituted heteroaryl,
• halo,
• NO2,
• NO,
• CN,
• ORa,
• 287
• wherein Ra is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,
• 288
• wherein Rb is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• 289
• wherein Rc and Rd are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• NReRf, wherein
• Re and Rf are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 290
• wherein Rb is defined as above;
• wherein Rc and Rd are defined as above;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Re and Rf are taken together with the nitrogen to which they are attached to form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R3 and R4 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN, or
• NReRf, wherein Re and Rf are defined as above;
• and
• Rg and Rh are defined as for Re and Rf above.

A compound of Formula VIII:

• 291
• or a pharmaceutically acceptable salt thereof, wherein:
• R2 is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heterocyclic and substituted heterocyclic,
• heteroaryl and substituted heteroaryl,
• halo,
• NO2,
• NO,
• CN,
• ORa,
• 292
• wherein Ra is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl,
• 293
• wherein Rb is H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• 294
• wherein Rc and Rd are independantly H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl;
• NReRf, wherein
• Re and Rf are each independently H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• C3-C7 cycloalkyl and substituted cycloalkyl,
• C5-C8 cycloalkenyl and substituted cycloalkenyl,
• aryl and substituted aryl, or
• 295
• wherein Rb is defined as above;
• wherein Rc and Rd are defined as above;
• aryl and substituted aryl,
• heteroaryl and substituted heteroaryl,
• heterocycloalkyl and substituted heterocycloalkyl, or
• Re and Rf are taken together with the nitrogen to which they are attached to form a 4, 5, 6, 7, or 8 membered ring having from 0 to 3 heteroatoms selected from N, O, and S, wherein said ring is optionally substituted by one or more substituents;
• R3 and R4 independently are H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NReRf, wherein Re and Rf are defined as above,
• R5 is hydrogen,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• ORa, wherein Ra is defined as above,
• 296
• wherein Rb is defined as above
• wherein Re and Rd are defined as above;
• halo,
• NO2,
• CN,
• NReRf as defined above,
• aryl or fused aryl,
• heterocyclic or fused heterocyclic,
• heteroaryl or fused heteroaryl,
• bicyclic heterocyclic or spiro heterocyclic,
• wherein fused aryl, fused heterocyclic, fused heteroaryl, bicyclic heterocyclic, or spiro heterocyclic can be substituted;
• and
• X and Y each independently are O, CH2, CH(C1-C7 alkyl), NH, N(C1-C7 alkyl), S, SO, or SO2;
• m is 0-14;
• Rj is H,
• OH,
• (O)nC1-C7 alkyl and substituted alkyl,
• (O)nC2-C7 alkenyl and substituted alkenyl,
• (O)nC2-C7 alkynyl and substituted alkynyl,
• wherein n is 0 or 1,
• halo,
• NO2,
• CN,
• NRkRm,
• wherein Rk and Rm independently are H,
• C1-C7 alkyl and substituted alkyl,
• C2-C7 alkenyl and substituted alkenyl,
• C2-C7 alkynyl and substituted alkynyl,
• 297
• alkyl and substituted alkyl, or
• Rk and Rm taken together with the nitrogen to which they are attached form a 3- to 7-membered ring containing from 1 to 3 heteroatoms selected from N, O, and S, said ring being unsubstituted or substituted with 1, 2, 3, or 4 substituent groups.

A compound which is:

• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-[3-(1-methylaminoethyl)pyrrolidin-1-yl]pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-pyrrolidin-1-yl-pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-6-[3-(1-hydroxyethyl)pyrrolidin-1-yl-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-((3S, 4S) and (3R,4R)-3-aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methyl-pyrido[1,2-c]pyrimidine-1,3-dione;
• hydrochloride;
• and
• 2-Amino-6-[4-(1-aminoethyl)-3,3-dimethylpyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methyl-pyrido[1,2-c]pyrimidine-1,3-dione;
• hydrochloride;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-[3-(1-methylaminoethyl)pyrrolidin-1-yl]-pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-pyrrolidin-1-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-6-[3-(1-hydroxyethyl)pyrrolidin-1-yl-5-methyl-pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-((R)-1-aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[(R)-3-((S)-1-aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[4-(1-aminoethyl)-3,3-dimethyl-pyrrolidin-1-yl]-4-cyclopropropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-(3-aminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[3-(1-aminoethyl)-4-methylpyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[3-(1-amino-1-phenylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(2-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(4-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(2,4-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-3-[1-amino-1-(2,6-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(2,4,6-trifluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-methylpropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-cyclopropylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-phenylmethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-fluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2,2-difluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-fluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-methylethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-pyridin-2-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-fluorocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-pyridin-3-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-pyridin-4-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-amino-5-fluorohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(3-phenylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(3-pyridin-2-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(3-pyridin-3-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(3-pyridin-4-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(piperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(4-methylpiperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• N-{1-[1-(2-Amino-4-cyclopropyl-7-fluoro-5-methyl-1,3-dioxo-2,3-dihydro-1H-pyrido[1,2-c]pyrimidin-6-yl)pyrrolidin-3-yl]ethyl}methanesulfonamide,
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-octahydropyrrolo[3,4-b]pyridin-6-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(7-amino-5-azaspiro[2.4]hept-5-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(thiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(1-methyl-2,3-dihydro-1H-isoindol-5-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-6-(7-hydroxymethyl-5-azaspiro[2.4]hept-5-yl)-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(3-amino-4-methoxyiminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(3-methylaminomethylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylthiophen-3-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)-3-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(5-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(5-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(5-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-pyridin-4-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethylpyridin-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylpyridin-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(6-aminomethylpyridin-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylpyrimidin-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-pyrimidin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(2-aminomethylpyrimidin-5-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-pyrimidin-5-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-pyrazin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(6-aminomethylpyrazin-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(6-aminomethylpyridin-2-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(2-aminomethylpyridin-3-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(2-aminomethylpyridin-3-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(2-aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(6-aminomethylpyridin-2-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(6-aminomethylpyridin-2-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[4-(2-aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(2-aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[4-(6-aminomethylpyridin-2-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-4-ylthiophen-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[4-(1-aminoethyl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-((3S, 4S) and (3R,4R)-3-aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(3-aminomethylpyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido-[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(7-amino-5-azospiro[2.4]hept-5-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]primidine-1,3-dione;
• 2-Amino-6-[3-(aminooxazol-4-yl-methyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminooctahydroisoindol-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-methylethyl)pyrrolidine-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• and
• 6-Chloro-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-[3-(1-methylaminoethyl)pyrrolidin-1-yl]pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-pyrrolidin-1-yl-pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-6-[3-(1-hydroxyethyl)pyrrolidin-1-yl-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-((3S, 4S) and (3R,4R)-3-aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• hydrochloride;
• and
• 2-Amino-6-[4-(1-aminoethyl)-3,3-dimethylpyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• hydrochloride;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-[3-(1-methylaminoethyl)pyrrolidin-1-yl]-pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-pyrrolidin-1-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-6-[3-(1-hydroxyethyl)pyrrolidin-1-yl-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-((R)-1-aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[(R)-3-((S)-1-aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[4-(1-aminoethyl)-3,3-dimethyl-pyrrolidin-1-yl]-4-cyclopropropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-(3-aminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[3-(1-aminoethyl)-4-methylpyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 2-Amino-6-[3-(1-amino-1-phenylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(2-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(4-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(2,4-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[11-amino-1-(2,6-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-{3-[1-amino-1-(2,4,6-trifluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-methylpropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-cyclopropylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-phenylmethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-fluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2,2-difluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-fluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-methylethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-pyridin-2-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-fluorocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-pyridin-3-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-pyridin-4-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-amino-5-fluorohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(3-phenylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(3-pyridin-2-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(3-pyridin-3-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(3-pyridin-4-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(piperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(4-methylpiperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• N-{1-[1-(2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-1,3-dioxo-2,3-dihydro-1H-pyrido[1,2-c]pyrimidin-6-yl)pyrrolidin-3-yl]ethyl}methanesulfonamide,
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-octahydropyrrolo[3,4-b]pyridin-6-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(7-amino-5-azaspiro[2.4]hept-5-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(thiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(1-methyl-2,3-dihydro-1H-isoindol-5-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-6-(7-hydroxymethyl-5-azaspiro[2.4]hept-5-yl)-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(3-amino-4-methoxyiminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(3-methylaminomethylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylthiophen-3-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)-3-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(5-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(5-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(5-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-pyridin-4-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethylpyridin-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylpyridin-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(6-aminomethylpyridin-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(5-aminomethylpyrimidin-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-pyrimidin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(2-aminomethylpyrimidin-5-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-pyrimidin-5-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-pyrazin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(6-aminomethylpyrazin-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(6-aminomethylpyridin-2-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(2-aminomethylpyridin-3-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(2-aminomethylpyridin-3-yl)thiophen-3-yl]4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(2-aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(6-aminomethylpyridin-2-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[5-(6-aminomethylpyridin-2-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[4-(2-aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(2-aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-4-ylthiophen-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[4-(1-aminoethyl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[(R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-((3S, 4S) and (3R,4R)-3-aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(3-aminomethylpyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido-[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(7-amino-5-azospiro[2.4]hept-5-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]primidine-1,3-dione;
• 2-Amino-6-[3-(aminooxazol-4-yl-methyl)pyrrolidin-1-yl]-4-cyclopropyl -7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminooctahydroisoindol-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2,8-Diamino-6-[3-(1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro -5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2,8-Diamino-6-(3-aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(3-aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2,2-difluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl -7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2,2-difluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl -7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-(4-aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-4-cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-hydroxyethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-hydroxyethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-2-hydroxyethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-[3-(1-amino-1-methylethyl)pyrrolidine-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• and
• 6-Chloro-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-Chloro-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-Chloro-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2-Amino-6-chloro-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 8-Amino-6-hloro-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 2,8-Diamino-6-hloro-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• or a pharmaceutically acceptable salt thereof.

A compound which is:

• 4-Cyclopropyl-7-fluoro-5-methyl-6-[3-(1-methylaminoethyl)pyrrolidin-1-yl]pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-pyrrolidin-1-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-6-[3-(1-hydroxyethyl)pyrrolidin-1-yl-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[(R)-3-((R)-1-Aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 6-[(R)-3-((S)-1-Aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 6-[4-(1-Aminoethyl)-3,3-dimethylpyrrolidin-1-yl]-4-cyclopropropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 6-(3-Aminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methyl-pyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 6-[3-(1-Aminoethyl)-4-methylpyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione hydrochloride;
• 6-[3-(1-Amino-1-phenylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(4-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2,4-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2,6-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2,4,6-trifluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-methylpropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-cyclopropylmethyl)pyrrolidin-1-yl]4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-phenylmethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2,2-difluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-fluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-methylethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-pyridin-2-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-fluorocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-pyridin-3-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-pyridin-4-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Amino-5-fluorohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(3-phenylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(3-pyridin-2-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(3-pyridin-3-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(3-pyridin-4-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(piperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(4-methylpiperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• N-{1-[1-(4-Cyclopropyl-7-fluoro-5-methyl-1,3-dioxo-2,3-dihydro-1H-pyrido[1,2-c]pyrimidin-6-yl)pyrrolidin-3-yl]ethyl}methanesulfonamide;
• 4-Cyclopropyl-7-fluoro-5-methyl-6(octahydropyrrolo[3,4-b]pyridin-6-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(7-Amino-5-azaspiro[2.4]hept-5-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(thiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(1-methyl-2,3-dihydro-1H-isoindol-5-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-6-(7-hydroxymethyl-5-azaspiro[2.4]hept-5-yl)-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(3-Amino-4-methoxyiminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-cyclopropyl-7-fluoro-5-methyl-6-(3-methylaminomethylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylthiophen-3-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)-3-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(5-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(5-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(5-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-pyridin-4-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethylpyridin-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylpyridin-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(6-Aminomethylpyridin-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylpyrimidin-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-pyrimidin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(2-Aminomethylpyrimidin-5-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-pyrimidin-5-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-pyrazin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(6-Aminomethylpyrazin-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(6-Aminomethylpyridin-2-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(2-Aminomethylpyridin-3-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(2-Aminomethylpyridin-3-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(2-Aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(6-Aminomethylpyridin-2-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(6-Aminomethylpyridin-2-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[4-(2-Aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(2-Aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[4-(6-Aminomethylpyridin-2-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methyl-6-(4-pyridin-4-ylthiophen-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• and
• 6-[4-(1-Aminoethyl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-[3-(1-methylaminoethyl)pyrrolidin -1-yl]pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-pyrrolidin-1-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-6-[3-(1-hydroxyethyl)pyrrolidin-1-yl-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[(R)-3-((R)-1-Aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[(R)-3-((S)-1-Aminoethyl)-pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[4-(1-Aminoethyl)-3,3-dimethylpyrrolidin-1-yl]-4-cyclopropropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(3-Aminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)-4-methylpyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-phenylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl -7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(4-fluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl -7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2,4-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2,6-difluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-{3-[1-Amino-1-(2,4,6-trifluorophenyl)methyl]pyrrolidin-1-yl}-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-methylpropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-cyclopropylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-phenylmethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-fluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2,2-difluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-fluorocyclopropyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-methylethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-pyridin-2-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-fluorocyclopropyl)-4-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-pyridin-3-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-1-pyridin-4-ylmethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Amino-5-fluorohexahydrocyclopenta[c]pyrrol-2-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(3-phenylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(3-pyridin-2-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(3-pyridin-3-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(3-pyridin-4-ylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(piperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(4-methylpiperazin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• N-{1-[1-(4-Cyclopropyl-7-fluoro-5-methoxy-1,3-dioxo-2,3-dihydro-1H-pyrido[1,2-c]pyrimidin-6-yl)pyrrolidin-3-yl]ethyl}methanesulfonamide, 4-Cyclopropyl-7-fluoro-5-methoxy-6(octahydropyrrolo[3,4-b]pyridin-6-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(7-Amino-5-azaspiro[2.4]hept-5-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(thiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(1-methyl-2,3-dihydro-1H-isoindol-5-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-6-(7-hydroxymethyl-5-azaspiro[2.4]hept-5-yl)-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(3-Amino-4-methoxyiminopyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-cyclopropyl-7-fluoro-5-methoxy-6-(3-methylaminomethylpyrrolidin-1-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylthiophen-3-yl)-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)-3-fluoropyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethylthiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethylthiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-(5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(6-methyl-5,6-dihydro-4H-thieno[2,3-c]pyrrol-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(5-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(5-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(5-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-4-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-3-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-2-ylthiophen-3-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-pyridin-4-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethylpyridin-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylpyridin-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(6-Aminomethylpyridin-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(5-Aminomethylpyrimidin-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-pyrimidin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(2-Aminomethylpyrimidin-5-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-pyrimidin-5-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-pyrazin-2-ylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(6-Aminomethylpyrazin-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(6-Aminomethylpyridin-2-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(2-Aminomethylpyridin-3-yl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(2-Aminomethylpyridin-3-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(2-Aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(6-Aminomethylpyridin-2-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[5-(6-Aminomethylpyridin-2-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[4-(2-Aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(2-Aminomethylpyridin-3-yl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[4-(6-Aminomethylpyridin-2-yl)thiophen-3-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 8-Amino-6-[3-(1-aminoethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 8-Amino-6-(3-aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(3-Aminomethyl-4-fluoropyrrolidin-1-yl)-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2,2-difluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2,2-difluoroethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-(4-Aminomethyl-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-cyclopropyl-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-6-[3-(1,2-dihydroxyethyl)pyrrolidin-1-yl]-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5-methoxy-8-methylpyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[3-(1-Amino-2-hydroxyethyl)pyrrolidin-1-yl]-4-cyclopropyl-7-fluoro-5,8-dimethylpyrido[1,2-c]pyrimidine-1,3-dione;
• 4-Cyclopropyl-7-fluoro-5-methoxy-6-(4-pyridin-4-ylthiophen-2-yl)pyrido[1,2-c]pyrimidine-1,3-dione;
• 6-[4-(1-Aminoethyl)thiophen-2-yl]-4-cyclopropyl-7-fluoro-5-methoxypyrido[1,2-c]pyrimidine-1,3-dione;
• or a pharmaceutically acceptable salt thereof.