Compositions and methods for treating and preventing memory impairment using citicoline

A method for preparing a composition for use in treating or preventing memory impairment or cognitive dysfunction, comprising the steps of:

• providing an effective amount of citicoline, or a pharmaceutically-acceptable salt thereof;
• providing an effective amount of one or more second compounds selected from the group consisting of linoleic acid and linolenic acid;
• and
• combining said citicoline with said one or more second compounds to form a pharmaceutically-acceptable preparation.

A method for preparing a composition for use in treating or preventing memory impairment or cognitive dysfunction, comprising the steps of:

• providing an effective amount of choline or a pharmaceutically-acceptable salt thereof;
• providing an effective amount of cytidine or a pharmaceutically-acceptable salt thereof;
• and
• providing an effective amount of uridine or a pharmaceutically-acceptable salt thereof.

A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:

• administering an effective amount of choline or a pharmaceutically-acceptable salt thereof;
• administering an effective amount of cytidine or a pharmaceutically-acceptable salt thereof;
• administering an effective amount of uridine or a pharmaceutically-acceptable salt thereof;
• and
• continuing said administration for a period of at least about six weeks.

A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:

• administering an effective amount of choline or a pharmaceutically-acceptable salt thereof;
• administering an effective amount of cytidine or a pharmaceutically-acceptable salt thereof;
• and
• continuing said administration for a period of at least about six weeks.

A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:

• administering an effective amount of choline or a pharmaceutically-acceptable salt thereof;
• administering an effective amount of uridine or a pharmaceutically-acceptable salt thereof;
• and
• continuing said administration for a period of at least about six weeks.

A method of preventing or treating cognitive disorders or memory impairment, comprising the steps of:

• administering an effective amount of cytidine or a pharmaceutically-acceptable salt thereof;
• administering an effective amount of uridine or a pharmaceutically-acceptable salt thereof;
• and
• continuing said administration for a period of at least about six weeks.