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US 2003/0114409 A1Published application
Facilitation of RNA interference
OwnerCraig C. Mello, Chun-Chieh Chen +1inventors
InventorsCraig C. Mello, Chun-Chieh Chen, Darryl Conte JR.
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Abstract
The present invention features compositions and methods to induce or enhance RNAi in cells, systems, and organisms using molecules that mediate RNAi in invertebrates such as C. elegans.
Claims17
A method for inducing or enhancing RNA interference (RNAi) in a cell, the method comprising
- (a) obtaining a cell, and
- (b) increasing the expression or activity of an RNA-dependent RNA polymerase (RdRP) in the cell.
A vector comprising a nucleic acid molecule encoding an RdRP.
A transgenic non-human mammal that expresses an ego-1 or rrf-1 sequence.
Dependencies are inferred from the claim text.