Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function
OwnerMatthew D. Linnik, Bonnie Hepburninventors
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Abstract
The invention provides methods treating lupus nephritis based in individuals with significantly impaired renal function, and methods of selecting individuals for treatment based on significantly impaired renal function. The treatment entails administration of a conjugate comprising a non-immunogenic valency platform molecule and at least two double stranded DNA epitopes, such as DNA molecules, which bind to anti-DNA antibodies from the patient. The invention also provides methods of identifying individuals suitable for treatment for lupus, based on assessing renal function to identify those individuals with significant impairment of renal function.
Claims27
A method of reducing incidence of renal flares in a systemic lupus erythematosus patient having significantly impaired renal function, comprising administering to the patient an effective amount of a conjugate comprising a non-immunogenic valency platform molecule and two or more double stranded DNA (dsDNA) epitopes, wherein the double stranded DNA epitopes are polynucleotides.
A method of treating systemic lupus erythematosus (SLE) in an individual, comprising selecting an individual having SLE and significantly impaired renal function, and administering to the individual an effective amount of a conjugate comprising a non-immunogenic valency platform molecule and two or more double stranded DNA (dsDNA) epitopes, wherein the dsDNA epitopes are polynucleotides.
A method of treating systemic lupus erythematosus (SLE) in an individual, comprising selecting an individual having (a) SLE, (b) significantly impaired renal function, and (c) antibodies with high affinity to a polynucleotide epitope a conjugate comprising a non-immunogenic valency platform molecule and two or more polynucleotides, said polynucleotides comprisine at least one double stranded DNA epitope, and administering to the individual an effective amount of said conjugate.
Dependencies are inferred from the claim text.