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OwnerMalaya Chatterjee, Kenneth A. Foon +1inventors
InventorsMalaya Chatterjee, Kenneth A. Foon, Sunil K. Chatterjee
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The present invention relates to monoclonal antibody 1A7. This is an anti-idiotype produced by immunizing with an antibody specific for ganglioside GD2, and identifying a hybridoma secreting antibody with immunogenic potential in a multi-step screening process. Also disclosed are polynucleotide and polypeptide derivatives based on 1A7, including single chain variable region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the 1A7 antibody overcomes immune tolerance and induces an immune response against GD2, which comprises a combination of anti-GD2 antibody and GD2-specific T cells. The invention further provides methods for treating a disease associated with altered GD2 expression, particularly melanoma, neuroblastoma, glioma, soft tissue sarcoma, and small cell carcinoma Patients who are in remission as a result of traditional modes of cancer therapy may be treated with a composition of this invention in hopes of reducing the risk of recurrence.
Monoclonal antibody 1A7.
An antibody producing cell deposited under ATCC Accession No. HB-11786, and the progeny thereof.
A polynucleotide comprising a sequence encoding a polypeptide with immunological activity of monoclonal antibody 1A7, wherein the polypeptide comprises at least 5 consecutive amino acids from a variable region of monoclonal antibody 1A7.
An isolated polynucleotide comprising a region of at least 20 consecutive nucleotides that is capable of forming a stable duplex with a polynucleotide consisting of the light chain variable region encoding sequence of SEQ. ID NO:1 under conditions where the region does not form a stable hybrid with a polynucleotide consisting of a variable region encoding sequence of a sequence selected from the group consisting of SEQ. ID NOS:17-26.
An isolated polynucleotide comprising a region of at least 20 consecutive nucleotides that is capable of forming a stable duplex with a polynucleotide consisting of the heavy chain variable region encoding sequence of SEQ. ID NO:3 under conditions where the region does not form a stable hybrid with a polynucleotide consisting of a variable region encoding sequence of a sequence selected from the group consisting of SEQ. ID NOS:27-44.
A polypeptide having immunological activity of monoclonal antibody 1A7, wherein the polypeptide comprises at least 5 consecutive amino acids from a variable region of monoclonal antibody 1A7.
21 A polypeptide according to claim 19, wherein the variable region is from a heavy chain.
Anti-idiotype monoclonal antibody 1A7, having all the identifying characteristics of ATCC Accession No. HB-11786.
Dependencies are inferred from the claim text.