Water soluble paclitaxel derivatives
AssigneePG-TXL Company, L.P.
InventorsChun Li, Sidney Wallace, Dong-Fang Yu, David J. Yang
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Abstract
Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
Claims75
A method for treating cancer in a subject, comprising administering to a subject having cancer a water soluble conjugate comprising a taxoid in combination with an antibiotic.
A method for treating cancer in a subject, comprising administering to a subject having cancer a water soluble conjugate comprising a taxoid in combination with doxorubicin.
A method for treating cancer in a subject, comprising administering to a subject having cancer a water soluble conjugate comprising a taxoid in combination with daunorubicin.
Dependencies are inferred from the claim text.