Use of steroidal alkaloids to reverse multidrug resistance
OwnerMordechai Liscovitch, Yaakov Lavieinventors
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Abstract
The invention provides steroidal alkaloids for inhibiting or reversing multidrug resistance in cancer or in bacterial, fungal or parasitic infections. The steroidal alkaloid may be administered to the patient alone or in combination with an anticancer, antibacterial, antifungal or antiparasitic agent. Examples of steroidal alkaloids include members of the solanidane or spirosolane e.g. tomatidine, families, and C-nor-D-homo steroid such as of the jervane or veratramine families.
Claims49
Use of a steroidal alkaloid or a pharmaceutically acceptable salt thereof in the preparation of a medicament for inhibiting or reversing multidrug resistance in cancer or in bacterial, fungal or parasitic infections.
A pharmaceutical composition for the inhibition or treatment of multidrug resistance in cancer or in bacterial, fungal or parasitic infections comprising as an active ingredient one or more steroidal alkaloids or pharmaceutically acceptable salts thereof, together with one or more pharmaceutically acceptable carriers, excipients or diluents.
A method for the inhibition of development of drug resistance or for reversal of multidrug resistance in a patient suffering from cancer or from a bacterial fungal or parasitic infection which comprises administering to said patient an effective amount of a steroidal alkaloid or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.