Methods and compositions for treating lesions of the respiratory epithelium
OwnerDaniel K. Podolskyinventor
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Abstract
This invention features methods of treating lesions of the airway epithelium by local or systemic administration of intestinal trefoil peptides. The intestinal trefoil peptide can be administered either alone or in combination with one or more therapeutic agents.
Claims49
A method for treating lesions of the respiratory epithelium in a mammal, comprising administering to said mammal a composition comprising a therapeutically effective amount of a trefoil peptide, or a biologically active fragment thereof.
The method of claim l, wherein said biologically active fragment is ITF15-73, ITF21-73, ITF1-72, ITF15-72, or ITF21-72.
A pharmaceutical composition suitable for inhalation administration, wherein said composition comprises a trefoil peptide, or a biologically active fragment thereof, and a pharmaceutically acceptable carrier.
A composition suitable for inhalation administration comprising a trefoil peptide or a biologically active fragment thereof, encoded by an isolated nucleic acid sequence that hybridizes under high stringency conditions with the sequence of SEQ ID NO.:
- 4, SEQ ID NO.:
- 5, SEQ ID NO.:
- 6, SEQ ID NO.:
- 7, SEQ ID NO.:
- 8, or SEQ ID NO.:
- 9.
Dependencies are inferred from the claim text.