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US 2003/0114383 A1Published application
Calcitonin-like sequence expressed by gonadotropes of the anterior pituitary
OwnerGirish Shahinventor
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Abstract
A cDNA sequence has been identified for an anterior pituitary-derived peptide (pit-CT) produced and secreted by the pituitary cells. The pit-CT has substantial sequence homology to calcitonin (CT) and has biological properties similar to salmon calcitonin (SCT). The pit-CT may be used to treat various diseases, such as osteoporosis, Pagets, and Prolactinoma.
Claims18
An isolated nucleic acid sequence encoding a peptide produced and secreted by the pituitary cells, selected from the group consisting of:
- a) a nucleic acid sequence having at least 90% homology with nucleotides of SEQ. ID. No. 1;
- and
- b) a nucleic acid sequence encoding a peptide having an amino acid sequence which has at least 90% homology with the amino acids of SEQ. ID. No. 2 or SEQ. ID. No. 3 or SEQ. ID. No. 4.
Dependencies are inferred from the claim text.