Methods related to the A-C repeat Z-sequence upstream from the aldose reductase gene
OwnerDavid A. Fryburg, Solomon S. Klioze +2inventors
InventorsDavid A. Fryburg, Solomon S. Klioze, Patrice M. Milos, Peter J. Oates
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Abstract
This invention relates to methods of characterizing subjects and methods of treatment or prevention of diseases and pathological conditions relating to the polymorphic A-C repeat sequence located approximately 2.1 kb upstream from the aldose reductase gene.
Claims53
A characterization method comprising:
- determining the value of n of the (A-C)n repeat Z sequence associated with each allele of the aldose reductase gene of a subject;
- and
- characterizing said subject as having the attribute of preferentially benefiting from the administration of an agent for prevention or treatment of a disease or pathological condition that is mediated by having at least one allele of said Z sequence wherein the value of n is less than 24, with the proviso that the value of n of at least one allele of said subject is determined to be less than 24.
A characterization method comprising:
- determining the value of n of the (A-C)n repeat Z sequence associated with each allele of the aldose reductase gene of a subject;
- and
- characterizing said subject as having the attribute of being likely to develop a disease or pathological condition that is mediated by having at least one allele of said Z sequence wherein the value of n is less than 24, with the proviso that the value of n of at least one allele of said subject is determined to be less than 24.
A method of treatment or prevention of complications associated with diabetes mellitus comprising administering to a subject an agent for treatment or prevention of a disease or pathological condition that is mediated by having at least one allele of the (A-C)n repeat Z sequence associated with the aldose reductase gene wherein the value of n is less than 24, wherein said subject has been characterized as having at least one allele of said Z sequence wherein n is less than 24.
Dependencies are inferred from the claim text.