Adhesion preventive membrane, method of producing a collagen single strand, collagen nonwoven fabric and method and apparatus for producing the same

An adhesion preventive membrane comprising a laminated film-like material having a nonwoven fabric layer composed of collagen fibers and a sponge layer composed of collagen, the laminated film-like product having on a surface thereof a coating layer containing a mixture of collagen and hyaluronic acid.

A method of producing a continuous collagen single strand, characterized in that a strand-like collagen is dehydrated/coagulated in a hydrophilic organic solvent having a water content of about 10% or less and then dried under conditions of a relative humidity of about 50% or less and a temperature of about 42° C. or less.

A collagen nonwoven fabric characterized by comprising first and second layers composed of a plurality of collagen strand-like materials spun out of a solubilized collagen solution as a spinning dope, and arranged substantially in parallel, the first and second layers being laminated and bonded to each other so that directions of arrangements of the strand-like materials of the first and the second layers are at an angle therebetween.

A method of producing a collagen nonwoven fabric, comprising winding up substantially in parallel a collagen strand-like material spun out of a solubilized collagen solution as a spinning dope around a plate-like member rotating with respect to a fixed rotation axis to form a first layer, and further winding up the collagen strand-like material substantially in parallel so as to form an angle to a direction of arrangement of the strand-like material forming the first layer to form a second layer.

An apparatus for producing a collagen nonwoven fabric, characterized by comprising (1) a plate-like member serving as a section around which collagen strand-like materials spun out of a solubilized collagen solution as a spinning dope are wound up, (2) an inner shaft connected to the plate-like member, (3) a cylindrical outer shaft having a bore that can accommodate the inner shaft and a tip with an oblique cut edge, (4) driving mechanisms for independently rotating the outer shaft and the inner shaft, respectively, and (5) a control mechanism for controlling the driving mechanisms to control rotations of the outer shaft and the inner shaft, respectively, the apparatus having a structure in which the plate-like member is rotatable in a horizontal direction with respect to a surface of the plate-like member about a connection part to the inner shaft as an axis, and in which the inner shaft is accommodated inside the outer shaft, with the cut edge on the tip of the outer shaft contacting a periphery of the plate-like member, whereby a function is provided which automatically changes the direction of the plate-like member to wind up the collagen strand-like materials in a plurality of directions of the plate-like member.