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AssigneePeter MacCallum Cancer Institute
InventorsLouise Elizabeth Purton, David Norman Haylock, Paul John Simmons, Steven James Collins
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The present invention relates to methods for self renewal of stem cells. In particular the invention relates to stem cells of increased transplant potential or enhanced self renewal, stem cell cultures derived therefrom and uses of the stem cell cultures for treatment and particularly for transplantation and gene therapy protocols. In a first aspect of the present invention there is provided a stem cell which maintains functional capacity upon self renewal or cell division in culture. In another aspect of the present invention, there is provided a method of culturing self renewal stem cells to maintain or enhance functional capacity upon self renewal, said method comprising subjecting said stem cells to an effective amount of a retinoid or equivalent thereof or modulating expression and/or activity of an RAR or equivalent thereof in the stem cell.
A stem cell which maintains functional capacity upon self renewal or cell division in culture.
A method of culturing self renewal stem cells to maintain or enhance functional capacity upon self renewal, said method comprising subjecting said stem cells to an effective amount of a retinoid or equivalent thereof.
A method of inducing self renewal of stem cells, said method comprising subjecting said stem cells to an effective amount of a retinoid or equivalent thereof.
A method of altering self renewal of stem cells said method comprising modulating expression and/or activity of an RAR or equivalent thereof in said stem cells.
A method of inducing differentiation of a stem cell, said method comprising decreasing expression and/or activity of RAR or equivalent thereof in said stem cell.
Dependencies are inferred from the claim text.