Histamine H2 receptor and uses
AssigneeOrigene Technologies, Inc.
InventorsKarl F. Kovacs, Gilbert Jay
Life of this patent
Estimating the term…
Abstract
The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.
Claims17
An isolated human H2R polynucleotide which codes without interruption for an amino acid sequence set forth in SEQ ID NO 2, or a complement thereto.
An isolated human H2R polynucleotide comprising,
- polynucleotide sequence having 95% or more sequence identity to the polynucleotide sequence set forth in SEQ ID NO 2 and which codes without interruption for H2R, or a complement thereto.
An isolated H2R polynucleotide, comprising:
- a polynucleotide coding for amino acids 360-422 of SEQ ID NO 2, specific fragments thereof, or complements thereto
An isolated antibody which is specific for a polypeptide having amino acids 360-422 of SEQ ID NO 2, or specific fragments thereof.
Dependencies are inferred from the claim text.