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US 2003/0113828 A1Published application
Compositions and methods for modulating Syk function
OwnerMark H. Ginsberg, Darren G. Woodsideinventors
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Abstract
Methods are provided for identifying agents which modulate the interaction of tyrosine kinases of the Syk family with integrins. Also provided are compositions and methods for using these agents to modulate tyrosine kinases of the Syk family and to treat disease such as thrombosis, inflammation, metastasis and tumor cell growth in a subject.
Claims8
A method for identifying agents which modulate the Syk family of tyrosine kinases comprising:
- contacting an agent with a protein mimetic comprising an integrin cytoplasmic domain in the presence of Syk;
- and
- detecting changes in the interaction of Syk with the cytoplasmic domain, wherein any changes in the interaction of Syk with the cytoplasmic domain are indicative of the agent being a modulator of activity of the Syk family of tyrosine kinases.
A composition which modulates a tyrosine kinase of the Syk family comprising an agent which changes the interaction of the tyrosine kinase of the Syk family with an integrin.
Dependencies are inferred from the claim text.