Hemogen-EDAG: novel nuclear factors expressed in hematopoietic development
OwnerLi Li, Li Yanginventors
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Abstract
A novel murine gene, designated Hemogen (hemopoietic gene) is sequentially expressed in active hematopoietic sites and downregulated during blood cell differentiation. Hemogen is a nuclear protein. A human homologue of Hemogen, named EDAG, which maps to chromosome 9q22, a leukemia breakpoint, exhibits also specific expression in hematopoietic tissues and cells. Hemogen and EDAG play an important role in hematopoietic development and neoplasms.
Claims19
An isolated nucleic acid molecule that encodes a mammalian protein Hemogen/EDAG that is selectively expressed in developing or immature hematopoietic cells.
A polypeptide that is selectively expressed in developing or immature hematopoietic cells, encoded by a nucleic acid molecule having the sequence SEQ ID NO:1 or SEQ ID NO:5, or a fragment, homologue or functional derivative of said polypeptide.
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