Canine peroxisome proliferator activated receptor gamma

An isolated polynucleotide comprising a polynucleotide sequence that encodes a polypeptide sequence of SEQ ID NO:

• 2.

An isolated polynucleotide comprising a polynucleotide sequence that encodes a polypeptide sequence having at least about 98% amino acid identity with the polypeptide sequence that is encoded by the polynucleotide sequence of SEQ ID NO:

• 1.

An isolated polynucleotide characterized as hybridizing under high stringency conditions with a polynucleotide sequence of SEQ ID NO:

• 1.

An isolated polynucleotide comprising a polynucleotide sequence having at least about 92% nucleotide identity with the polynucleotide sequence of SEQ ID NO:

• 1.

An isolated canine PPARγ polypeptide.

An isolated polypeptide comprising a polypeptide sequence having at least about 98% amino acid identity with the polypeptide sequence that is encoded by the polynucleotide sequence of SEQ ID NO:

• 1.

An expression vector comprising a polynucleotide encoding a canine PPARγ polypeptide.

An expression vector comprising a polynucleotide sequence that encodes a polypeptide sequence of SEQ ID NO:

• 2.

An expression vector comprising a polynucleotide sequence having at least about 92% nucleotide identity with the polynucleotide sequence of SEQ ID NO:

• 1.

A transformed cell comprising an inserted polynucleotide comprising a polynucleotide sequence that encodes a canine PPARγ polypeptide, or a progeny cell thereof comprising said polynucleotide sequence.

A transformed cell comprising an inserted polynucleotide comprising a polynucleotide sequence that encodes a polypeptide sequence of SEQ ID NO:

• 2, or a progeny cell thereof comprising said polynucleotide sequence.

A transformed cell comprising an inserted polynucleotide comprising a polynucleotide sequence having at least about 92% nucleotide identity with the polynucleotide sequence of SEQ ID NO:

• 1, or a progeny cell thereof comprising said polynucleotide sequence.

A transformed cell comprising an inserted polynucleotide comprises a polynucleotide sequence having at least about 95% nucleotide identity with the polynucleotide sequence of SEQ ID NO:

• 1, or a progeny cell thereof comprising said polynucleotide sequence.

A transformed cell comprising an inserted polynucleotide comprises a polynucleotide sequence of SEQ ID NO:

• 1, or a progeny cell thereof comprising said polynucleotide sequence.

An isolated antibody which specifically binds to a polypeptide encoded by the sequence of SEQ ID NO:

• 1.

A microarray comprising an isolated polynucleotide encoding a canine PPARγ polypeptide, or a complimentary nucleotide sequence thereof.

A microarray comprising a nucleotide sequence comprising at least 25 contiguous nucleotides of the nucleotide sequence of SEQ ID NO:

• 1, or a complimentary nucleotide sequence thereof.

A method comprising administering a PPARγ activating amount of a PPARγ activator to a mammal of the Canidae family, preferably a member of the species, Canis lupus familiaris, having a disease, condition or disorder which is beneficially treated by an activator of canine PPARγ.

A method comprising administering a PPARγ inhibiting amount of a PPARγ activator to a mammal of the Canidae family, preferably a member of the species, Canis lupus familiaris, having a disease, condition or disorder which is beneficially treated by an activator of canine PPARγ.