Identification of modulators of gpr55 activity
OwnerAndrew Brown, Alan Wiseinventors
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Abstract
A method for identification of an agent that modulates activity of G-protein coupled receptor 55 (GPR 55), which method comprises: (i) contacting a test agent with GPR 55 or a variant thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 55 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 55 activity.
Claims17
A method for identification of an agent that modulates activity of G-protein coupled receptor 55 (GPR 55), which method comprises:
- (i) contacting a test agent with GPR 55 or a variant thereof which is capable of coupling to a G-protein;
- and
- (ii) monitoring for GPR 55 activity in the presence of a G-protein;
- thereby determining whether the test agent modulates GPR 55 activity.
A method according to any one of the preceding claims wherein the variant has at least 80% sequence identity to SEQ ID NO:
- 2.
A method according to any one of the preceding claims wherein the G-protein is G1-protein.
A test kit suitable for identification of an agent that modulates GPR 55 activity, which kit comprises:
- (a) GPR 55 or a variant thereof which is capable of coupling to a Gi-protein;
- and
- (b) means for monitoring GPR 55 activity.
Dependencies are inferred from the claim text.