Orphan receptor
AssigneeKaro Bio AB
InventorsGeorg Kuiper, Eva L. K. Enmark, Jan-Ake Gustafsson
Life of this patent
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Abstract
This invention relates to a novel estrogen receptor-related nuclear receptor, hereinafter termed “ERβ” having the amino acid sequence of FIGS. 1, 13A or 14A or substantially the same amino acid sequence as the amino acid sequence shown in FIGS. 1, 13A or 13B or an amino acid sequence functionally similar to that sequence. The invention also relates to DNA sequences encoding the receptor. The receptor may be useful in isolating molecules for the treatment of disorders such as prostate cancer, benign prostatic hyperplasia, osteoporosis or cardiovascular disorders and in the testing of substances for estrogenic and other hormonal effects.
Claims12
A receptor, ERβ, having the amino acid sequence of FIGS. 1, 13A or 14A or substantially the same amino acid sequence as the amino acid sequence shown in FIGS. 1, 13A or 14A or an amino acid sequence functionally similar to those sequences.
A drug design method comprising comparing binding of a test compound to ERα and to ERβ.
hERβ and functional equivalents thereof.
Dependencies are inferred from the claim text.