Systems and methods for the generation of crystalline polymorphs
AssigneeThe Regents of the University of Michigan
InventorsAdam J. Matzger, Meidong Lang, Kibum Kim
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Abstract
The present invention relates to systems and methods for generating polymorphs of compounds. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline polymorphs that find use as improved drugs, pigments, explosives, nonlinear optical crystals, solid-state reactive compounds, and other polymorphic materials.
Claims45
A method for identifying polymorphs, comprising:
- a. providing:
- i. a sample comprising a compound;
- and
- ii. a polymer library comprising two or more different polymers;
- b. contacting said polymer library with said sample under conditions that promote crystal formation from said sample;
- and
- c. analyzing formed crystals for polymorph structure.
A composition comprising a solution of dissolved acetaminophen in contact with orthorhombic acetaminophen crystals obtained from said solution.
A method for producing orthorhombic acetaminophen crystals, comprising exposing a solution containing acetaminophen to a polymer.
A composition comprising C-centered monoclinic carbamazepine.
A method for producing C-centered monoclinic carbamazepine, comprising exposing a solution containing carbamazepine to a polymer selected from the group consisting of hydroxypropyl cellulose, poly(4-methylpentene), poly(α-methylstyrene, and poly(p-phenylene ether-sulfone).
A method of treating a subject comprising administering a composition comprising C-entered monoclinic carbamazepine to said subject.
Dependencies are inferred from the claim text.