Neurogenesis inducing genes
AssigneeThe Institute of Physical and Chemical Research
InventorsKatsuhiko Mikoshiba, Jun Aruga, Takeharu Nagai, Katsunori Nakata
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Abstract
The present invention relates to neurogenesis inducing genes. In particular, the present invention provides neurogenesis inducing genes coding for Zic proteins, vectors containing such genes, host cells containing such vectors, proteins produced by such host cells, antibodies raised to such proteins, and therapeutic agents or agents for gene therapy for nervous diseases.
Claims20
An isolated nucleic acid encoding a protein having at least a portion of the amino acid sequence selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 42 and SEQ ID NO:
- 44.
A composition comprising a protein having at least a portion of the amino acid sequence selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 42 and SEQ ID NO:
- 44.
A method for gene therapy, comprising the steps of:
- a) providing i) a subject, and ii) a composition comprising a nucleic acid having at least a portion of the sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 41 and SEQ ID NO:
- 43;
- and
- b) delivering said composition to said subject.
A method for producing a neurogenesis inducing protein, comprising the steps of:
- a) providing a composition comprising a recombinant vector, wherein said recombinant vector comprises a nucleic acid having a portion of the sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 41 and SEQ ID NO:
- 43, and a host cell;
- b) transforming said recombinant vector into said host cell to produce a transformant;
- and
- c) culturing said transformant to produce a neurogenesis inducing protein.
Dependencies are inferred from the claim text.