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OwnerLex M. Cowsert, Brenda F. Baker +8inventors
InventorsLex M. Cowsert, Brenda F. Baker, John McNeil, Susan M. Freier, Henri M. Sasmor, Douglas G. Brooks, Cara Ohashi, Jacqueline R. Wyatt, Alexander H. Borchers, Timothy A. Vickers
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Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising generating a library of nucleobase sequences in silico according to defined criteria.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising evaluating in silico a plurality of virtual oligonucleotides according to defined criteria.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising robotically synthesizing a plurality of defined oligonucleotide compounds.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising robotically assaying a plurality of oligonucleotide compounds for one or more desired physical, chemical or biological properties.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising generating a library of nucleobase sequences in silico according to defined criteria and evaluating in silico a plurality of virtual oligonucleotides having said nucleobase sequences according to defined criteria.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising evaluating in silico a plurality of virtual oligonucleotides according to defined criteria and robotically synthesizing a plurality of oligonucleotide compounds corresponding to said plurality of virtual oligonucleodites.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising evaluating in silico a plurality of virtual oligonucleotides according to defined criteria and robotically assaying a plurality of oligonucleotide compounds corresponding to said virtual oligonucleotides for one or more desired physical, chemical or biological properties.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising generating a library of nucleobase sequences in silico according to defined criteria and robotically synthesizing a plurality of oligonucleotide compounds having said nucleobase sequences.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising robotically synthesizing a plurality of oligonucleotide compounds and robotically assaying said plurality of oligonucleotide compounds for one or more desired physical, chemical or biological properties.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising generating a library of nucleobase sequences in silico according to defined criteria and robotically assaying a plurality of oligonucleotide compounds having said nucleobase sequences for one or more desired physical, chemical or biological properties.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence, comprising the steps of:
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence, comprising the steps of:
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence, comprising the steps of:
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence, comprising the steps of:
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence, comprising the steps of:
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence, comprising the steps of:
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence, comprising the steps of:
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising generating a library of antisense nucleobase sequences in silico according to defined criteria.
A method of generating a set of compounds that modulate the expression of a target nucleic acid sequence comprising evaluating in silico a plurality of virtual oligonucleotides according to defined criteria.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising robotically synthesizing a plurality of antisense compounds.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising robotically assaying a plurality of antisense compounds for one or more desired physical, chemical or biological properties.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising generating a library of nucleobase sequences in silico according to defined criteria and evaluating in silico a plurality of virtual oligonucleotides having said nucleobase sequences according to defined criteria.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising evaluating in silico a plurality of virtual oligonucleotides according to defined criteria and robotically synthesizing a plurality of oligonucleotide compounds.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising evaluating in silico a plurality of virtual oligonucleotides according to defined criteria and robotically assaying a plurality of oligonucleotide compounds for one or more desired physical, chemical or biological properties.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising generating a library of nucleobase sequences in silico according to defined criteria and robotically synthesizing a plurality of oligonucleotide compounds having said nucleobase sequences.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising robotically synthesizing a plurality of oligonucleotide compounds and robotically assaying said plurality of oligonucleotide compounds for one or more desired physical, chemical or biological properties.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising generating a library of nucleobase sequences in silico according to defined criteria and robotically assaying a plurality of oligonucleotide compounds having said nucleobase sequences for one or more desired physical, chemical or biological properties.
A method of identifying one or more nucleic acid sequences amenable to antisense modulation comprising the steps of:
A method of identifying one or more nucleic acid sequences amenable to antisense modulation, comprising the steps of:
A method of identifying one or more nucleic acid sequences amenable to antisense modulation, comprising the steps of:
A method of identifying one or more nucleic acid sequences amenable to antisense modulation, comprising the steps of:
A method of identifying one or more nucleic acid sequences amenable to antisense modulation, comprising the steps of:
A method of identifying one or more nucleic acid sequences amenable to antisense modulation, comprising the steps of:
A method of identifying one or more nucleic acid sequences amenable to antisense modulation, comprising the steps of:
A computer formatted medium comprising computer readable instructions for identifying active compounds.
A computer formatted medium comprising computer readable instructions for performing a method of identifying one or more nucleic acid sequences amenable to antisense modulation.
A computer formatted medium comprising one or more nucleic acid sequences amenable to antisense modulation in computer readable form.
Dependencies are inferred from the claim text.