Back to results
US 2003/0113708 A1Published application
Methods of screening for toxicity of test compounds
AssigneeBristol-Myers Squibb Company
InventorsOliver P. Flint, Frederic Moulin, Stephen K. Durham
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods of screening drug candidates for toxic effects on human cells. The invention provides methods for determining idiosyncratic toxicity of test compounds.
Claims13
A method of determining idiosyncratic toxicity of a compound comprising:
- a) contacting a test compound with a cell which expresses a Phase I enzyme;
- b) contacting the cell with a cell viability indicator to determine whether the test compound has generated a toxic metabolite;
- c) wherein generation of a toxic metabolite indicates that the test compound exhibits idiosyncratic toxicity.
Dependencies are inferred from the claim text.