US 2003/0113478 A1 · Surface coating method and coated device

Abstract

A multi-step method of forming a coating on a substrate, such as a stent or graft, is disclosed. The steps of the method include treating the surface with a plasma formed at or near atmospheric pressure to form one or more active species on the surface until a desired surface density of the active species is formed, and exposing the treated surface to a selected gas or liquid under conditions effective to convert the active species to a stable functional group. The exposed surface surface may be contacted with a surface-modifying group under conditions effective to covalently attach the surface-modifying group to the functional group. Also disclosed is a substrate having a to bioactive/biocompatible coating and/or a drug-releasable coating prepared by the method.

Claims32

Dependent claims

A method of forming on the surface of a substrate a coating having a selected surface density of a selected chemical group, said method comprising the steps of:

(a) treating the surface with a plasma formed at or near atmospheric pressure to form one or more active species on said surface;
(b) continuing said treating until a desired surface density of the active species is formed;
(c) exposing the treated surface to a selected gas or liquid under conditions effective to convert the active species to a stable functional group;
and
(d) optionally contacting the exposed surface to a surface-modifying group under conditions effective to covalently attach the surface-modifying group to said functional group,
where the selected chemical group on the surface is the stable functional group or the surface-modifying group covalently attached thereto.

3 more elements

Dependencies are inferred from the claim text.

Surface coating method and coated device

Life of this patent

Surface coating method and coated device

Life of this patent

Abstract

Claims32