Liposome coated with polyhydroxyalkanoate and production method thereof
AssigneeCanon Kabushiki Kaisha
InventorsTsuyoshi Nomoto, Tetsuya Yano, Shinya Kozaki, Tsutomu Honma
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Abstract
To provide a structure that has both drug holding capability and sustained releasability a liposome and mechanical strength of polyhydroxyalkanoate, is excellent in holding capability for hydrophilic drugs and other water-soluble substances as well as liphophilic drugs and other hydrophobic substances, and is capable of controlling the sustained releasability. To coat with polyhydroxyalkanoate at least part of the outer wall of the liposome.
Claims51
A polyhydroxyalkanoate-coated liposome, wherein at least part of an outer wall thereof is coated with polyhydroxyalkanoate.
A method for preparing a polyhydroxyalkanoate-coated liposome, at least a part of an outer wall of the liposome being coated with polyhydroxyalkanoate, the method comprising the steps of:
- immobilizing a polyhydroxyalkanoate synthase on a surface of the liposome dispersed in an aqueous medium;
- adding 3-hydroxyacyl CoA as a substrate;
- and
- coating at least a part of the surface of the liposome with polyhydroxyalkanoate by carrying out polyhydroxyalkanoate synthesis reaction.
Dependencies are inferred from the claim text.