Method for producing a bone material enriched with bone growth factors
AssigneeTutogen Medical GmbH
InventorLudwig Baumgartner
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Abstract
The aim of the invention is to produce a bone material which is enriched with bone growth factors and whose bone growth factors are released in a delayed manner after surgically applied in the body. To this end, the invention provides a method according to which the bone material is loaded with a bone growth factor or with a mixture of bone growth factors and is then coated with a reabsorbable substance.
Claims13
A method of manufacturing a bone material enriched with bone growth factors, wherein the surface and/or the interior of the bone material is charged with at least one bone growth factor (BMP) and is sheathed with a resorbable material, wherein the bone material is initially charged by spraying on, trickling on or sucking in of a solution or suspension of the bone growth factor or by immersing into a solution or suspension of the bone growth factor and the bone material treated in this manner is subsequently sheathed.
A method in accordance with any one of the preceding claims, characterized in that collagen is used as the resorbable material in the form of a solution, of a suspension, as a gel or gelatin, polyglycol acid, polylactic acid, oxycellulose or fabric adhesive, for example fibrin adhesive or acrylic adhesive.
A method in accordance with any one of the preceding claims, characterized in that bone material is used in the form of blocks, chips or powder.
A method in accordance with any one of the preceding claims, characterized in that the bone growth factor(s) are homogeneously distributed in a solution or suspension of the resorbable material, bone material is subsequently introduced into this solution in the form of powder or chips and the intermediate product obtained in this manner is subsequently dried, preferably freeze dried, to form a sponge-like body.
A method in accordance with any one of the preceding claims, characterized in that fully or partly demineralized bone material is used.
A method in accordance with any one of the preceding claims, characterized in that the bone material is charged with at least one antibiotic.
A method in accordance with any one of the preceding claims, characterized in that the charged bone material is freeze dried.
A bone material manufactured by a method in accordance with at least one of the preceding claims.
Dependencies are inferred from the claim text.