Apparatus and methods for preventing or treating failure of hemodialysis vascular access and other vascular grafts
AssigneeVascular Therapies, LLC
InventorsSriram S. Iyer, Nicholas N. Kipshidze, Victor V. Nikolaychik
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Abstract
This invention is a prosthetic device generally placed on the outside surface of the vessel or graft which then elutes antiproliferative drugs or agents from a drug-eluting matrix material. Methods of perivascular antiproliferative drug administration also are disclosed.
Claims36
A method of preventing or treating vasculoproliferative disease in vascular structures, which comprises the step of:
- administering extravascularly and locally an antiproliferative effective amount of an antiproliferative agent to the vascular structure.
An implantable, antiproliferative agent-administering perivascular sleeve adapted to be placed in contact with the exterior of a vascular structure comprising:
- a) A flexible, cylindrical, bioabsorbing, agent-eluting matrix material, the material having a vascular-sized lumen passing substantially through said matrix material, the matrix material having dispersed therein:
- b) An antiproliferative agent.
A method of treating vasculoproliferative disease in hemodialysis access sites which comprises the step of:
- administering extravascularly and locally an antiproliferation effective amount of an antiproliferation agent to the access site.
A method of suppressing vasculoproliferative response in a vascular structure comprising the step of:
- administering vascular extravascularly and locally an antiproliferation effective amount of an antivasculoproliferation agent to the vascular structure.
A method of treating smooth muscle cell (SMC) hyperplasia in vascular structures which comprises the step of:
- administering, extravascularly and locally, an antiSMC effective amount of an anti SMC agent to the vascular structure.
A method of preventing or delaying failure of a hemodialysis access site by the extravascular and local administration of agents that prevent suppress or treat vasculoproliferative response or SMC hyperplasia.
An apparatus for local administration of agents for preventing or delaying failure of a hemodialysis vascular access site.
An apparatus comprising a vascular graft combined with one or more antiproliferative drugs.
Dependencies are inferred from the claim text.