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US 2003/0113346 A1Published application
Recombinant rabies vaccine and methods of preparation and use
AssigneeThomas Jefferson University
InventorsBernhard Dietzchold, D. Craig Hooper, Matthias J. Schnell
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Abstract
Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of anti-rabies immunity in a subject.
Claims30
A live rabies vaccine comprising a recombinant rabies virus genome, wherein the recombinant rabies genome comprises at least two G protein genes.
A method of producing a live rabies virus vaccine, comprising the steps of:
- (1) inserting one or more G protein genes into a rabies virus genome which already contains a G protein gene, to produce a recombinant rabies virus genome;
- (2) constructing an expression vector from the recombinant rabies virus genome;
- (3) transfecting a cell with the expression vector and recovering infectious recombinant rabies virus for use as a live rabies virus vaccine.
Dependencies are inferred from the claim text.