Affinity enhancement agents
AssigneeImmunomedics, Inc.
InventorsEdmund Rossi, Chien-Hsing Ken Chang
Life of this patent
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Abstract
This invention relates to a kit containing a multivalent, multi-specific binding protein and a carrier molecule. The binding protein has two or more binding sites where at least one binding site binds with a hapten moiety and at least one site binds with a target antigen. The carrier molecule contains a linking molecule that bears a diagnostic agent and/or a therapeutic agent and two or more haptens. The present invention further relates to bispecific diabodies that bind with hapten moieties and target antigens and to recombinant vectors useful for the expression of these-functional diabodies in a microbial host.
Claims28
A kit for delivering a diagnostic agent, a therapeutic agent, or a combination thereof to a target, comprising
- a. a multivalent, multi-specific binding protein comprising two or more binding sites, wherein at least one binding site has affinity towards a hapten moiety and at least one binding site has affinity towards a target antigen;
- and
- b. a carrier molecule comprising a diagnostic agent, a therapeutic agent, or a combination thereof, a linking molecule, and at least two hapten moieties positioned to permit simultaneous binding of said hapten moieties with said binding protein.
A multivalent, multi-specific binding protein comprising a histamine-succinyl-glycyl (HSG) binding site having an affinity towards molecules containing a HSG moiety and a carcinoembryonic antigen (CEA) binding site having an affinity towards CEA.
A carrier molecule, comprising a diagnostic agent, a therapeutic agent, or a combination thereof, a linking moiety, and two or more hapten moieties, wherein said hapten moieties are positioned to permit simultaneous binding of said hapten moieties with binding sites of one or more binding proteins.
Dependencies are inferred from the claim text.