Methods of modulation of the immune system
AssigneeThe Hospital for Sick Children
InventorsChaim M Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Gruebaum
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Abstract
Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.
Claims22
A method of modulating the immune system of an animal comprising administering to the animal an effective amount of a substance that modulates the expression, or activity of EphB6, or its active partner thereby modulating the immune system.
A method of modulating of a cell comprising administering to the cell, an effective amount of a substance that modulates the expression, or activity of EphB6, or its active partner thereby modulating the apoptosis.
A method of modulating cell proliferation comprising administering to the cell an effective amount of a substance which modulates the expression or activity of an EphB6 receptor or its active partners.
A method of modulating a T cell response in an animal comprising administering to the animal an effective amount of a substance that modulates EphB6 expression or activity or that of its partner such that the T cell response is modulated.
A method of treating a disorder of T-cell proliferation, an autoimmune disorder, a cell-associated autoimmune disorder, an allergic disorder in an animal, or a host versus transplant reaction comprising administering to the animal an effective amount of a combination of inhibitory or stimulatory soluble EphB6 ligand and/or soluble EphB6 receptor, or a ligand to an EphB6 active partner or soluble partner, thereby treating the disorder.
A method of promoting an anti-viral immune response in an animal comprising administering to the animal an effective amount of a substance that modulates the expression or activity of EphB6 or its active Eph partner thereby promoting the antiviral response in the animal.
A method for identifying a substance which is capable of binding to a purified and isolated EphB6 protein, comprising reacting the protein with at least one substance which potentially can bind with the protein under conditions which permit the formation of complexes between the substance and the protein, and assaying for complexes, for free substance, for non-complexed protein, or for activation of the protein.
A method for assaying a medium for the presence of an agonist or antagonist of the interaction of a purified and isolated a EphB6 protein and a substance which binds to the protein which comprises reacting the protein with a substance which is capable of binding to the protein and a suspected agonist or antagonist substance under conditions which permit the formation of complexes between the substance and the protein, and assaying for complexes, for free substance, for non-complexed protein, or for activation of the protein.
Dependencies are inferred from the claim text.