Skin barrier function and cohesion through enhanced stratum corneum acidification
AssigneeThe Regents of the University of California
InventorsPeter M. Elias, Kenneth R. Feingold, Joachim W. Fluhr, Theodora M. Mauro, Martin J. Behne
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Abstract
The integrity, barrier function, cohesion and antimicrobial defense of the stratum corneum pH are improved by acidification, which is achieved by the application of low pH buffers, enzymes, phospholipids or salts with monovalent cations.
Claims40
A method for treating the epidermis of a terrestrial mammalian subject suffering from a perturbed epidermal barrier function, said method comprising administering to said epidermis a topical composition comprising an active ingredient that acidifies the pH of the stratum corneum and is a member selected from the group consisting of phospholipases, phospholipids, salts with monovalent cations, and buffers with a pH less than 7.0, said active ingredient being present in a concentration that is effective in acidifying the pH of said epidermis and thereby improving barrier function.
A method for treating the epidermis of a terrestrial mammalian subject suffering from an impaired epidermal cohesion, said method comprising administering to said epidermis a topical composition comprising an active ingredient that acidifies the pH of the stratum corneum and is a member from the group consisting of phospholipases, phospholipids, salts with monovalent cations, and buffers with a pH less than 7.0, said active ingredient being present in a concentration that is effective in acidifying the pH of said epidermis and thereby improving epidermal cohesion.
Dependencies are inferred from the claim text.