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OwnerElena Revazova, Jeff Sebastianinventors
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The success of tissue transplantation, when immunological conflict is minimized, depends on the vascularization process. This process is very complex and requires time. During this time, transplanted tissue often has difficulty obtaining oxygen and nutrients. These factors have a profound influence on the survival of the transplanted tissue, especially if the tissue has poor angiogenic properties. For new vessel formation, endothelial cells from existing recipient microvessels must proliferate and migrate through the extracellular matrix into the transplanted tissue. However, if transplanted tissue is mixed with recipient endothelial cells or co-administered, vascularization and acceptance of auto-, allo-, and heterotransplants is enhanced. In addition, recipient endothelial cells can be used to enhance vascularization of three-dimensional tissue-engineered constructs.
A method of transplanting tissue into a recipient to enhance vascularization of the tissue comprising the steps of:
A tissue-engineered construct for implantation into a human recipient comprising a tissue from an allogenic donor and endothelial cells from the recipient.
An islet for implantation into a human recipient comprising an allogenic islet and recipient endothelial cells infused therein.
A method for treating a human recipient with diabetes comprising transplanting an allogenic islet and recipient endothelial cells into a transplantation site of the recipient.
Dependencies are inferred from the claim text.