Muscle cells and their use in cardiac repair
OwnerAlbert Edge, Jonathan Dinsmoreinventors
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Abstract
Muscle cells and methods for using the muscle cells are provided. In one embodiment, the invention provides transplantable skeletal muscle cell compositions and their methods of use. In one embodiment, the muscle cells can be transplanted into patients having disorders characterized by insufficient cardiac function, e.g., congestive heart failure, in a subject by administering the skeletal myoblasts to the subject. The muscle cells can be autologous, allogeneic, or xenogeneic to the recipient.
Claims83
A method of treating a dysfunctional heart comprising:
- identifying a subject in need of treatment for cardiac dysfunction;
- and
- delivering a composition comprising skeletal myoblasts to the subject's heart, wherein at least a portion of the skeletal myoblasts, or cells to which the skeletal myoblasts give rise, survive in the heart after delivery and express therein a marker characteristic of skeletal myoblast survival or differentiation.
A method of preparing a composition for transplantation into a subject's heart comprising steps of:
- obtaining a sample of muscle tissue from a subject;
- isolating a population of cells from the sample, wherein the population of cells comprises skeletal myoblasts;
- expanding the population in culture;
- and
- preparing the population that results from the expanding step to produce a transplantable composition comprising skeletal myoblasts characterized by the ability to survive, or to give rise to cells that survive, in the subject's heart after delivery and express therein a marker characteristic of skeletal myoblast survival or differentiation.
A transplantable composition comprising skeletal myoblasts, wherein the composition is characterized by an ability, when delivered to a subject's heart, to survive in the heart after delivery and there express a marker characteristic of skeletal myoblast survival or differentiation.
Dependencies are inferred from the claim text.