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US 2003/0113295 A1Published application
Methods and compositions for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
OwnerHaim Burstein, Anthony M. Stepaninventors
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Abstract
The present invention provides recombinant adeno-associated virus (rAAV) vectors encoding a tumor necrosis factor (TNF) antagonist and methods using these vectors to reduce levels of TNF in a mammal. The invention also provides methods of using these rAAV vectors in palliating TNF-associated disorders.
Claims39
A recombinant adeno-associated virus (rAAV) vector comprising a polynucleotide encoding a fusion polypeptide comprising an extracellular domain of tumor necrosis factor receptor (TNFR) and a constant domain of an IgG1 molecule.
Dependencies are inferred from the claim text.