Methods and compositions for pulmonary delivery of insulin
OwnerJohn S. Patton, Linda Foster +1inventors
InventorsJohn S. Patton, Linda Foster, Robert M. Platz
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Abstract
Systemic delivery of insulin to a mammalian host is accomplished by inhalation of a dry powder of insulin. It has been found that dry insulin powders are rapidly absorbed through the alveolar regions of the lungs.
Claims25
A method for aerosolizing a dose of insulin, said method comprising:
- providing insulin as a dry powder;
- dispersing an amount of the dry powder in a gas stream to form an aerosol;
- and
- capturing the aerosol in a chamber having a mouthpiece for subsequent inhalation by a patient.
An improved method for the respiratory delivery of insulin, wherein the improvement comprises delivering the insulin as a dry powder.
A method for preparing a stable, dry powder insulin composition, said method comprising:
- dissolving insulin in an aqueous buffer to form a solution;
- and
- spray drying the solution to produce substantially amorphous particles having an average size below 10 μm.
An insulin composition for pulmonary delivery, said composition comprising individual particles which include insulin present at from 5% to 99% by weight in a pharmaceutical carrier material and have a size below 10 μm.
An insulin composition consisting essentially of dry powder insulin having an average particle size below 10 μm.
Dependencies are inferred from the claim text.