Powders comprising anti-adherent materials for use in dry powder inhalers
OwnerJohn Nicholas Staniforthinventor
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Abstract
A powder for use in a dry powder inhaler comprises active material and additive material. The additive material comprises an anti-adherent material and the powder includes at least 60% by weight of active material. The inclusion of the additive material in the powder has been found to give an increased respirable fraction of the active material.
Claims36
A powder for use in a dry powder inhaler, the powder comprising active material and additive material, the additive material comprising an anti-adherent material and the powder including at least 60% by weight of active material based on the weight of the powder.
A powder according to any preceding claim, wherein the additive material includes one or more compounds selected from amino acids and derivatives thereof, and peptides and polypeptides having a molecular weight of between about 0.25 to 1000 kDa, and derivatives thereof.
A powder according to any preceding claim, wherein the additive material includes one or more water soluble compounds.
A powder according to any preceding claim, wherein the additive material includes dipolar ions.
A powder according to any preceding claim wherein the additive material includes a glidant material.
A powder according to any preceding claim, wherein the active material includes a β2-agonist.
A powder according to any preceding claim, wherein the powder comprises particles of active material and particles of additive material.
A powder according to any preceding claim, wherein the powder comprises at least 0.1% by weight of additive material based on the weight of the powder.
A powder according to any preceding claim, wherein the powder comprises not more than 10% by weight of additive material based on the weight of the powder.
A powder according to any preceding claim, wherein the powder comprises not more than 5% by weight of additive material based on the weight of the powder.
A powder according to any preceding claim, wherein at least 95% by weight of the active particles have a particle size less than 10 μm.
A powder according to any preceding claim, wherein the powder includes less than 20% by weight of constituents other than the active material and the anti-adherent material.
A powder for use in a dry powder inhaler the powder comprising active particles and additive material, at least 90% by weight of the powder particles having a particle size of less than 63 μm, the powder including at least 60% by weight of active particles based on the weight of the powder.
A powder for use in a dry powder inhaler, the powder comprising active particles and additive material, the additive material forming at least a partial coating on the surfaces of the particles of active material, the powder including at least 60% by weight of active material based on the weight of the powder, at least 90% by weight of the particles of the powder having a particle size less than 63 μm.
A powder for use in a dry powder inhaler the powder being substantially as herein described.
A dry powder inhaler containing powder substantially as herein described having reference to FIG. 1.
Use of an anti-adherent material in a powder for use in a dry powder inhaler, for improving the flow characteristics of the powder, the powder comprising at least 60% by weight of active material based on the weight of the powder.
Dependencies are inferred from the claim text.