Formulations for pulmonary delivery
AssigneeUniversity Technology Corporation
InventorsDerrick Katyama, Mark C. Manning, Kathleen A. Stringer, John E. Repine
Life of this patent
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Abstract
Formulations for pulmonary delivery that include a protein and a non-physiological surfactant at or above the CMC of the surfactant, and methods for preparing and using the same.
Claims113
A composition suitable for aerosolization comprising a biologically active protein and a non-physiological surfactant, wherein the non-physiological surfactant is included in an amount greater than the CMC of the surfactant.
A method for preparing an aerosol composition, the method comprising:
- (a) preparing a composition comprising a biologically active protein and a non-physiological surfactant, wherein the non-physiological surfactant is included in an amount greater than the CMC of the surfactant;
- and
- (c) aerosolizing the composition of (a).
A method for pulmonary delivery of a biologically active protein to a subject, the method comprising administering an effective amount of an aerosolized surfactant composition, wherein the composition comprises a biologically active protein and a non-physiological surfactant, and wherein the non-physiological surfactant is included in an amount greater than the CMC of the surfactant.
The method of 64 where the inflammatory lung disease is acute respiratory distress syndrome (ARDS).
The method of 89 where the inflammatory lung disease is acute respiratory distress syndrome (ARDS).
A method for inhibiting pulmonary inflammation in a subject comprising administering to a subject an effective amount of an aerosolized surfactant composition, wherein the composition comprises a biologically active tissue-type plasminogen activator and a non-physiological surfactant, wherein the non-physiological surfactant is included in an amount greater than the CMC of the surfactant, and whereby pulmonary inflammation is reduced in the subject.
The method of 98 where the inflammatory lung disease is acute respiratory distress syndrome (ARDS).
Dependencies are inferred from the claim text.