Degradation-resistant glucocorticosteroid formulations
OwnerMina Buenafae, Michael Brucato +1inventors
InventorsMina Buenafae, Michael Brucato, Kai Zhang
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Abstract
The present invention thus provides chemically and physically stable formulations of glucocorticosteroids obtained by formulating the glucocorticosteroid with a cosolvent, a propellant and a radical quencher where the glucocorticosteroid remains chemically and physically stable under standard conditions.
Claims52
A pharmaceutical composition comprising a glucocorticosteroid, a propellant, a cosolvent, and a radical quencher.
A pressurized metered dose inhaler comprising a container equipped with a metering valve and containing a pressurized aerosol formulation comprising a glucocorticosteroid, a propellant, a cosolvent, and a radical quencher.
A method for the treatment of a bronchial disorder in a mammal by administering a pharmaceutical formulation comprising a glucocorticosteroid, a propellant, a cosolvent, and a radical quencher.
A method for preventing oxidative degradation of an aerosol formulation including a glucocorticosteroid, a propellant, and a cosolvent, the method comprising introducing a radical quencher to the formulation.
Dependencies are inferred from the claim text.