Labeled compounds for measuring the function of the muscarinic acetylcholine nervous system
AssigneeHamamatsu Photonics K.K.
InventorsHideo Tsukada, Kengo Sato, Shingo Nishiyama, Norihiro Harada
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Abstract
A muscarinic acetylcholine nervous system labeled compound for positron emission tomography measurement of the present invention has a structure represented by undermentioned general formula (I): 1 [in the formula, W represents one selected from the group consisting of groups represented by undermentioned formulae (II) and (III): 2 (in the formulae, R represents one selected from the group consisting of an 11C-labeled ethyl group and an 11C-labeled propyl group), and in the case that W is a group represented by above-mentioned formula (II), above-mentioned formula (I) is the (+)-isomer].
Claims3
A muscarinic acetylcholine nervous system labeled compound for positron emission tomography measurement, characterized by having a structure represented by the following general formula (I):
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- [in the formula, W represents one selected from the group consisting of groups represented by the following formulae (II) and (III):
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- (in the formulae, R represents one selected from the group consisting of an 11C-labeled ethyl group and an 11C-labeled propyl group), and in the case that W is a group represented by the formula (II), the formula (I) is the (+)-isomer].
A method of manufacturing a muscarinic acetylcholine nervous system labeled compound for positron emission tomography measurement, characterized by comprising a step of obtaining a compound represented by the following formula (I):
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- from an 11C-labeled alkyl halide represented by the following formula (IV):
- R—X (IV)
- and a benzilic acid piperidyl ester represented by the following formula (V):
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- [In the formulae, R represents one selected from the group consisting of an 11C-labeled ethyl group and an 11C-labeled propyl group, X represents a halogen atom, W′ represents one selected from the group consisting of a (+)3-piperidyl group and a 4-piperidyl group, and W represents one selected from the group consisting of groups represented by the following formulae (II) and (III):
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- (in the formulae, R represents one selected from the group consisting of an 11C-labeled ethyl group and an 11C-labeled propyl group).]
Dependencies are inferred from the claim text.