Method for adhesion of polymers to metal-coated substrates

Abstract

The present invention provides methods for improving the a&esion of gels to metalcoated substrates. In particular, the present invention provides a method comprising the steps of forming a thiol or disulfide self-assembled monolayer on the metal-coated substrate prior to deposition of the gel structures. The invention further provides devices fabricated according to the methods of the invention, comprising a substrate having a surface, a noble metal layer deposited on the substrate surface, a self-assembled monolayer comprised of bifunctional molecules having a thiol or disulfide end and a polymerizable end formed on the noble metal layer, and a plurality of gel pads a&Bred to the self-assembled monolayer. The devices of the invention are advantageously used for performing assays using optical and/or electrochemical detection methods.

Dependencies are inferred from the claim text.