Methods and devices for analysis of x-ray images
AssigneeImaging Therapeutics, Inc.
InventorsPhilipp Lang, Daniel Steines
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Abstract
The present invention relates to methods and devices for analyzing x-ray images. In particular, devices, methods and algorithms are provided that allow for the accurate and reliable evaluation of bone structure from x-ray images.
Claims82
A method to derive information on bone structure from an image comprising:
- (a) obtaining an image from a subject;
- (b) analyzing the image obtained in step (a) to derive quantitative information on bone structure;
- and
- (c) comparing the information on bone structure obtained from the image to a database of bone structure measurements obtained from selected subjects.
A method of treating a bone condition comprising
- (a) obtaining an image from a subject;
- (b) analyzing the image obtained in step (a) to derive quantitative information on bone structure;
- (c) diagnosing a bone condition based on the analysis of step (b);
- and
- (d) selecting and administering a suitable treatment to said subject based on said diagnosis.
A method of determining bone mineral density from an x-ray image, the method comprising the steps of
- (a) determining density of one or more internal standards in said image;
- (b) creating a weighted mean between the values obtained in step (a);
- (c) utilizing said weighted mean to determine bone mineral density of bone in said image.
A method of determining bone structure from an x-ray image comprising the steps of
- (a) identifying one or more internal standards on said x-ray image;
- (b) determining the density or structure of said standard;
- and
- (c) utilizing the density, structure or combinations thereof of said standard to determine bone structure of the x-ray image.
A method of evaluating bone disease in a subject, the method comprising the steps of:
- (a) obtaining an x-ray image from said subject, wherein said image includes one or more bones;
- (b) assessing bone mineral density in at least one anatomic region of said image;
- (c) assessing bone structure in said region;
- and
- (d) combining said assessments of bone mineral density and bone structure to evaluate bone disease.
A method of treating bone disease in a subject, the method comprising the steps of:
- (a) obtaining an image from said subject, wherein said image includes one or more bones;
- (b) assessing bone mineral density in at least one anatomic region of said image;
- (c) assessing bone structure in said region;
- (d) combining said assessments of bone mineral density and bone structure to evaluate bone disease;
- (e) selecting a therapy based on the evaluation of bone disease;
- and
- (f) administering said therapy to said subject.
A method for evaluating bone disease in a subject, the method comprising the steps of:
- (a) obtaining an image of said subject wherein said image includes one or more bones;
- (b) assessing bone structure of said bone in said image;
- (c) assessing one or more macro-anatomical parameters in said image;
- and
- (d) combining the assessments bone structure and macro-anatomical parameter assessment to evaluate bone disease.
A method to assess the presence or severity of a bone disease from an image comprising:
- (a) obtaining an image from a subject;
- (b) analyzing the image obtained in step (a) to derive quantitative information on bone structure;
- and
- (c) comparing the information on bone structure obtained from the image to a database of bone structure measurements obtained from selected subjects,
- thereby assessing the presence or severity of a disease.
A method for minimizing tube angulation of an x-ray tube that includes an x-ray film holder, comprising the steps of
- providing an attachment mechanism;
- and
- attaching the x-ray system to the x-ray film holder such that tube angulation is minimized.
A method for minimizing tube angulation of an x-ray tube that includes a dental x-ray film holder, comprising the steps of
- providing an x-ray tube alignment system;
- and
- aligning the x-ray system substantially perpendicular to the x-ray film such that tube angulation is minimized, wherein said alignment system uses optical aids.
Dependencies are inferred from the claim text.