Surface modification of a porous polymer monolith and products therefrom
AssigneeAdvion BioSciences, Inc.
InventorXian Huang
Life of this patent
Estimating the term…
Abstract
A process is provided for modifying a porous polystyrene monolith to render its internal pore surfaces grafted with alkyl groups, preferably of at least four carbon atoms, which includes the step of alkylating the monolith with a uniform liquid solution containing a Friedel-Crafts catalyst and an alkyl halide. A surface-modified monolith produced thereby is an efficient separation medium in reversed-phase liquid chromatography for both small and large biomolecules.
Claims37
A process for the surface modification of a porous polystyrenic monolith, comprising the steps of:
- (a) wetting the monolith internal through-pore surfaces with an organic solvent used in step (b);
- (b) treating the internal through-pore surfaces of said monolith by contacting said monolith pores with a uniform liquid solution comprising a Friedel-Crafts catalyst, an alkyl halide, and an organic solvent so as to alkylate the internal through-pore surfaces;
- and
- (c) removing the post-reaction solution from the alkylated through-pore surfaces by rinsing the organic solvent used in step (b) through said monolith.
A porous polystyrenic monolith comprising alkylated internal through-pore surfaces.
Dependencies are inferred from the claim text.