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US 2003/0111356 A1Published application
Combinatorial synthesis on arrays
OwnerMichael Paul Strathmanninventor
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Abstract
The present invention provides methods for synthesizing arrays of polymers. A barrier to a reaction is applied to select features of the array thereby limiting the reaction to the remaining features.
Claims9
A method for inhibiting a reaction, comprising:
- providing a substrate for the reaction and applying a barrier to the reaction on the substrate wherein the presence of the barrier is determined by an electrochemical process.
A method for synthesis of an array of separately formed polymers, comprising:
- (a) providing an array comprising distinct features wherein a feature comprises one or more functional groups,
- (b) using an electrochemical process to apply a barrier on a subset of the features wherein the barrier prevents effective coupling between a monomer having at least one protected functional group and the functional groups in the features,
- (c) coupling the monomers to the array,
- (d) removing the barrier,
- (e) if necessary, deprotecting the functional groups on the monomers coupled to the array, and
- (f) repeating steps (b) through (e) until at least two separate polymers are formed on distinct features of the array.
3 more elements
Dependencies are inferred from the claim text.