Process for the preparation of 4-haloalkylnicotinonitriles

Abstract

4-Haloalkylnicotinonitriles having the formula (I) 1 which are suitable as intermediates in the preparation of pesticides, are obtained by: (a) reacting a 3-amino-1-haloalkyl-2-propen-1-one RF—C(O)—CH═CH—NH2  (II) in a condensation reaction with a compound of the formula (III) to (VII), (R1Z)CH═CH—CN  (III) (R1Z)2CH—CH2—CN  (IV) Hal-CH═CH—CN  (V) Hal2CH—CH2CN  (VI) HC≡C—CN  (VII), to give a compound of the formula (VIII), (IX) and/or (X), RF—C(O)—CH═CH—NH—CH═CH—CN  (VIII) RF—C(O)—CH═CH—NH—CH(ZR1)—CH2—CN  (IX) RF—C(O)—CH═CH—NH—CH(Hal)-CH2—CN  (X), wherein RF is (C1-C4)-haloalkyl, R1 is alkyl, Hal is Cl or Br and each Z, independently, is O, S, NR1 or OCO; and (b) subjecting the reaction product to a ring closure reaction.

Dependencies are inferred from the claim text.