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US 2003/0097024 A1Published application
Taxane synthesis method and intermediates
AssigneeFlorida State University
InventorsRobert A. Holton, Phong Vu, Tawfik Gharbaoui, Vincent Reboul
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Abstract
A process for the preparation of a composition having the formula: 1 in which a compound having the formula: 2 is treated with a base and a silylating agent.
Claims21
A process for the preparation of a composition having the formula:
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- the process comprising treating a compound having the formula:
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- with a base and a silylating agent.
1 more element
A process for the preparation of a compound having the formula:
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- the process comprising treating a compound having the formula:
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- with an alkyl metal species or with a Lewis acid in the presence of a tertiary amine base, wherein P2 is hydrogen or a hydroxyl protecting group.
1 more element
A process for the preparation of a compound having the formula:
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- the process comprising treating a compound having the formula:
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- with a Lewis acid in the presence of a tertiary amine base, wherein P2 is hydrogen or a hydroxy protecting group.
1 more element
A compound selected from the group consisting of:
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- wherein P2, P7, P9, P10 and P13 are independently selected from hydrogen and hydroxy protecting group.
Dependencies are inferred from the claim text.