Device for transdermal electrotransport delivery of fentanyl and sufentanil
AssigneeAlza Corporation
InventorsMary Southam, Keith J. Bernstein, Henk Noorduin
Life of this patent
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Abstract
The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water soluble salt (e.g., fentanyl hydrochloride), preferably in a hydrogel formulation, for use in an electrotransport device (10). In accordance with the present invention, a transdermal electrotransport delivered dose of fentanyl/sufentanil is provided which is sufficient to induce analgesia in (e.g., adult) human patients suffering from moderate-to-severe pain associated with major surgical procedures.
Claims20
A device (10) for transdermally delivering fentanyl by electrotransport, the device including a donor reservoir (26) containing the fentanyl in a form to be delivered by electrotransport, a counter reservoir (28), a source of electrical power (32) electrically connected to the reservoirs (26,28) and a control circuit (19,40) for controlling magnitude and timing of applied electrotransport current, the device (10) characterized by:
- the reservoirs (26,28), the power source (32) and the control circuit (19,40) being effective to deliver by electrotransport about 20 μg to about 60 μg of fentanyl over a delivery period of up to about 20 minutes.
A device (10) for transdermally delivering sufentanil by electrotransport, the device including a donor reservoir (26) containing the sufentanil in a form to be delivered by electrotransport, a counter reservoir (28), a source of electrical power (32) electrically connected to the reservoirs (26,28) and a control circuit (19,40) for controlling magnitude and timing of applied electrotransport current, the device (10) characterized by:
- the reservoirs (26,28), the power source (32) and the control circuit (19,40) being effective to deliver by electrotransport about 2.3 μg to about 7.0 μg of sufentanil over a delivery period of up to about 20 minutes.
Dependencies are inferred from the claim text.