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US 2003/0083503 A1Published application
Synthesis of acylated keto amides from sulfonyl amides
OwnerDoug E. Frantz, Lisa F. Frey +3inventors
InventorsDoug E. Frantz, Lisa F. Frey, Karen Marcantonio, Jerry Anthony Murry, Richard Tillyer
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Abstract
Acylated ketoamides are prepared from sulfonyl amides and aldehydes or their related derivatives by a step of 1
Claims4
A method of forming a reaction product mixture substantially containing
- 12
- wherein
- R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, or aryl;
- R2 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, heterocyclalkyl, —O—C1-6alkyl, —O-aryl, —NH2, —NHC1-6alkyl, or —NH-aryl;
- R3 is C1-6alkyl, C3-7cycloalkyl, aryl, or heteroaryl;
- said method comprising:
- reacting
- 13
- in an effective amount of R3CHO or an effective amount of
- 14
- in an effective amount of a basic solvent.
8 more elements
A method of forming a reaction product mixture substantially containing
- 15
- wherein
- R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, or aryl;
- R2 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, heterocyclalkyl, —O—C1-6alkyl, —O-aryl, —NH2, —NHC1-6alkyl, or —NH-aryl;
- R3 is C1-6alkyl, C3-7cycloalkyl, aryl, or heteroaryl;
- said method comprising:
- reacting
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- in effective amount of R3CHO and an effective amount of a catalyst
- 17
- wherein R10, R11, and R12 each independently is hydrogen, C1-6alkyl, C3-7cycloalkyl, or aryl, optionally substituted with OH.
8 more elements
Dependencies are inferred from the claim text.