Antisense modulation of short heterodimer partner-1 expression
OwnerRosanne M. Crooke, Mark J. Grahaminventors
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of short heterodimer partner-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding short heterodimer partner-1. Methods of using these compounds for modulation of short heterodimer partner-1 expression and for treatment of diseases associated with expression of short heterodimer partner-1 are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding short heterodimer partner-1, wherein said compound specifically hybridizes with and inhibits the expression of a nucleic acid molecule encoding short heterodimer partner-1.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding short heterodimer partner-1.
Dependencies are inferred from the claim text.