Nucleotide vector, composition containing such vector, and vaccine for immunization against hepatitis
AssigneeInstitut Pasteur
InventorsMarie-Louise Michel, Maryline Mancini
Life of this patent
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Abstract
Nucleotide vector composition containing such vector and vaccine for immunization against hepatitis. Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A nucleotide vector composition when administered to even chronic HBV carriers is capable of breaking T cell tolerance to the surface antigens of hepatitis B virus. A vaccine preparation containing said bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers.
Claims16
A nucleotide sequence comprising a promoter homologous to the host and another regulatory sequence for the expression of a gene or a DNA coding complement for S, preS2-S1 or preS1-preS2-S.
A composition capable of inducing a cytotoxic response comprising a gene or complementary DNA coding for at least a portion of a virus protein, which is expressed in the muscle cells, and an internal promoter.
A non-lipid pharmaceutical composition comprising at least one substance capable of inducing a coagulating necrosis of the muscle fibers and either a vector comprising a gene or complementary DNA coding for at least a portion of a virus protein, and a promoter allowing the expression of the gene in the muscle cells or a complete or partial nucleotide sequence comprising a promoter homologous to the host and another regulatory sequence for the expression of a gene or a DNA coding complement for S, preS2-S, or preS1-preS2-S.
A composition for inducing a B and/or T cell response in chronic HBV carriers comprising a vector, wherein said vector comprises a gene or complementary DNA coding for at least a portion of a hepatitis B protein and a promoter.
Dependencies are inferred from the claim text.