Neuropilin antisense oligonucleotide sequences and methods of using same to modulate cell growth
AssigneeGenesense Technologies Inc.
InventorsJIM A. WRIGHT, AIPING H. YOUNG, YOON S. LEE
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Abstract
This invention relates to oligonucleotides complementary to the neuropilin genes which modulate tumor cell growth and angiogenesis in mammals. This invention is also related to methods of using such compounds in inhibiting the growth of tumor cells and angiogenesis in mammals. This invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.
Claims16
An antisense oligonucleotide from about 20 to about 100 nucleotides comprising a sequence selected from the group consisting of SEQ ID NOs:1-30 as set forth in Table 1 which oligonucleotide inhibits neuropilin expression.
A vector comprising an oligonucleotide sequence from about 20 to 100 nucleotides comprising a sequence selected from the group consisting of SEQ ID NOs:1-30 as set forth in Table 1 which oligonucleotide inhibits neuropilin expression.
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and an effective amount of the antisense oligonucleotide from about 20 to 100 nucleotides comprising a sequence selected from the group consisting of SEQ ID NOs:1-30 as set forth in Table 1 which inhibit neuropilin expression.
A method for inhibiting the growth of a mammalian tumor comprising, administering to a mammal suspected of having the tumor an effective amount of an antisense oligonucleotide from about 3 to about 100 nucleotides comprising a sequence complementary to a mammalian neuropilin mRNA under conditions such that the growth of the tumor is inhibited.
A method for inhibiting the metastasis of a mammalian tumor comprising, administering to a mammal suspected of having a metastatic tumor an effective amount of an antisense oligonucleotide from about 3 nucleotides to about 100 nucleotides comprising a sequence complementary to a mammalian neuropilin gene under conditions such that the metastasis of the tumor is inhibited.
A method for inhibiting neovascularization comprising, administering to a mammal an effective amount of an antisense oligonucleotide from about 3 nucleotides to about 100 nucleotides comprising a sequence complementary to a mammalian neuropilin gene under conditions such that neovascularization is inhibited.
Dependencies are inferred from the claim text.